Diabetes Online-Kongress 2021
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Dr. Sophie Steculorum
Sophie M. Steculorum, Ph.D. Nationality: French Date of birth: December 17th 1985 Work Address: Max Planck Institute for Metabolism Research Group “Neurocircuit Wiring and Function” Gleueler Str. 50 50931 Cologne, Germany E-mail: sophie.steculorum@sf.mpg.de Tel: +49-221-4726-226Fax: +49-221-4726-298 Handy: +49-151-7085-9945 Researcher unique identifier(s): ORCID (ID: 0000-0002-5665-2732), Google Scholar Sophie Steculorum Present positionSince 01.2017 Max Planck Research Group Leader Head of group “Neurocircuit Wiring and Function” Max Planck Institute for Metabolism Research, Cologne, Germany Website: http://www.sf.mpg.de/research/steculorumPrincipal investigator, Cluster of Excellence: Cellular Stress Responses in Aging-AssociatedDiseases (CECAD), Cologne, GermanyWebsite: http://cecad.uni-koeln.de/Dr-Sophie-Steculorum.460.0.htmlEducation2008-2011 Ph.D. in Neurobiology (summa cum laude with committee praise), University of Lille 2, France2006-2008 M.Sc. degree in Neuroscience and Physiology (high honors, valedictorian), University of Lille 2, France2006 B.Sc. degree in Cellular Biology and Physiology (honors), University of Artois, FranceAcademic research training2012-2016 Postdoctoral researcher Host: Professor Jens Brüning Institute: Max Planck Institute for Metabolism Research, Group of Neuronal Control of Metabolism / Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany2008-2011 Ph.D. in Neurobiology. Ph.D. title: “Hormonal programming of the hypothalamus: long term impact on energy homeostasis regulation” Supervisor: Dr. Sebastien Bouret Host institutes: University of Lille 2, Inserm U837 (Lille, France) and University of Southern California, The Saban Research Institute, Developmental Neuroscience Program (Los Angeles, USA). Time spent equally between both institutes.2006-2008 M.Sc in Neuroscience and Physiology M.Sc title: “Impact of maternal diabetes on the organization of hypothalamic feeding circuits and energy homeostasis in offspring” Supervisor: Dr. Sebastien BouretPublications 2017 Ruud J, Steculorum SM & Brüning. (2017) Neuronal control of peripheral insulin sensitivity and glucose metabolism. Nature Communications, 4;8:15259Steculorum SM, Timper K, Engström Ruud L, Evers N, Paeger L, Bremser S, Kloppenburg P & Brüning JC. Inhibition of P2Y6-signaling in AgRP-neurons reduces food intake and improves systemic insulin sensitivity in obesity. Cell Reports, 18(7):1587-1597.Timper K, Denson JL, Steculorum SM, Hellinger C, Engström Ruud L, Wunderlich CM, Rose-John S, Wunderlich FT & Brüning JC. IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling. Cell Reports, 11;19(2):267-28.2016 Steculorum SM*, Ruud J*, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess M, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P & Brüning JC. AgRP-neurons control systemic insulin sensitivity via myostatin-expression in brown-adipose tissue. Cell, 24;165(1):125-38. * Equal contributions. Steculorum SM & Brüning JC. Sweet mitochondrial dynamics in VMH neurons. Cell Metabolism,12;23(4):577-9. (Preview)Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Mauer J, Steculorum SM, Hampel B, Goldiau J, Alber J, Förster CY, Eming S.A, Schwaninger M, Ferrara N, Karsenty G & Brüning J.C. Myeloid cell-Derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity. 25;166(5):1338-1340, Cell. 2015 Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P & Brüning JC. Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP-neurons. Cell, 10;162(6):1404-17.Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, & Bouret SG. Neonatal ghrelin programs development of hypothalamic feeding circuits. Journal of Clinical Investigations, 125(2):846-58.2014 Steculorum SM & Brüning JC. Die another day: a painless path to longevity. Cell, 22;157(5):1004-6. (Preview) Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL & Brüning JC. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell, 156(3):495-509.Steculorum SM, Solas M & Brüning JC. The paradox of neuronal insulin action and resistance in the development of ageing-associated diseases. Alzheimer’s & Dementia, 10(1 Suppl):S3-11. (Review)Balland E, Steculorum SM*, Dam J*, Langlet F*, Caron E*, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG & Prévot V. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metabolism, 4;19(2):293-301. * Equal contributions.2013 Steculorum SM, Vogt MC & Brüning JC. Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits. Endocrinol Metab Clin North Am., 42(1):149-64. (Review)2011 Steculorum SM & Bouret SG. Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology, 152(11):4171-9. Steculorum SM & Bouret SG. Developmental actions of ghrelin. Peptides, 32(11):2362-6. (Review)Steculorum SM & Bouret SG. Emerging role of neuroendocrine programming in obesity. De Gruyter Edition, Perinatal Programming : The State of the Art, Edited by Plagemann Andreas; Chapter 11:107-128. (Book chapter)2009 D’Anglemont de Tassigny X, Campagne C, Steculorum SM & Prevot V. Estradiol induces physical association of nNOS with NMDA receptors and promotes NO formation via estrogen activation in neurons of the preoptic region in vitro. Journal of Neurochemistry,109(1):214-24.2008 Bouret SG, Caron E, Steculorum SM, Sachot C & Ishii Y. Leptin and hypothalamic control of reproduction. Médecine de la Reproduction Gynécologie Endocrinologie, 10(2):74-84. (Review)PatentInventors: Jens Brüning and Sophie Steculorum Title: Food intake, body weight and glucose metabolism regulation by modulation of P2Y6 receptor signaling Category: International Number: PCT/EP2015/058114Publication: 21/01/16Status: Application in progress (Application number EP 14 177 351.5 and EP 14 187 205.1)Awards and Fellowships2018 - ERC Starting Grant (Proposal name: PRiSM) - FENS EJN (Federation of European Neuroscience Societies European, Journal of Neuroscience) Young Investigator Prize 2018 - SNE Prize 2018 (Young Investigator Prize from the French Society of Neuroendocrinology), International Congress of Neuroendocrinology 2018, Toronto, Canda2017 - Peter Hans Hofschneider Prize (award from the Max Planck Society for groundbreaking research in Molecular Medicine)2016 - Nikon young scientist award (award from Nikon Company and the German Society for Cell Biology) 2014 - CECAD career-promoting senior postdoc grant (24 months funding for technician salary cost and bench fees)2013 - Alexander von Humboldt fellowship for postdoctoral researchers (24 months funding for grantee’s salary cost and bench fees) 2010 - Oral presentation award, 14th Annual meeting of the LARC-Neuroscience network, Lille, France - Poster presentation award from the University of Lille 2, Lille, France2009 - Poster award, 13th Annual meeting of the LARC-Neuroscience network, Caen, France2008 - Master thesis award from the University of Lille 2 (Valedictorian award) - Ph.D. fellowship from the Inserm2007 - Merit-based scholarships award from the Region-Nord-Pas-de-CalaisOral presentations and Symposia 2018 Novel regulators of the central control of food intake and systemic insulin sensitivity. The Rowett Institute, Aberdeen, Scotland. Invited institute seminar. Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-signaling. H3 Symposium on Purinergic Signalling in Obesity and Renal Pathophysiology, London, UK. Invited symposium. Novel regulators of the central control of food intake and systemic insulin sensitivity. Technical University of Munich, Munich, Germany. Invited institute seminar.2017 The hunger games: novel regulators of the central control of appetite and glucose homeostasis. Center of advanced european studies and research (Caesar), Bonn, Germany. Invited institute seminar. Central control of appetite and systemic insulin sensitivity. Institut Pasteur, Paris. Invited symposium.2016 Novel regulators of the central control of food intake and systemic insulin sensitivity. New Frontiers in Obesity Research Congress, Cordoba, Spain. Invited symposium. The hunger games: how the brain controls appetite and glucose homeostasis. 1st joint MPI Scientific Retreat, Cologne, Germany. Symposium. Novel regulators of the central control of food intake and systemic insulin sensitivity. International Regulatory Peptide Society 2016, Rouen, France. Invited symposium. New regulator of the central control of food intake and systemic insulin sensitivity. International Meeting of the German Society for Cell Biology (DGZ). Munich, Germany. Invited symposium. Novel regulator of orexigenic AgRP/NPY-neurons in control of food intake and insulin sensitivity. Robert Debré Hospital for mothers and children, Paris, France. Invited symposium. Chemogenetic and optogenetic approaches to investigate the central control of feeding and systemic insulin sensitivity. 8th Annual Meeting of the Danish Society for Pharmacology, Odense, Denmark. Symposium.2015 Hypothalamic control of energy and glucose homeostasis. 17th Annual Conference, Frontiers in Diabetes Research-Colombia University, New York, USA. Symposium.Novel regulator of orexigenic AgRP-neurons. 3rd British Society for Neuroendocrinology- French Neuroscience Society Joint Meeting, Lille, France. Invited symposium. Novel regulator of hypothalamic circuits. COST Action Scientific Meeting, Prato, Italy. Symposium. 2014 Insulin receptor and hypothalamic programming. 8th International Congress of Neuroendocrinology, Sydney, Australia. Symposium. 2013 Hypothalamic regulation of hormonal inputs. 11th Annual Meeting of the French Neuroscience Society, Lyon, France. Symposium. 2011 Hormonal programming of hypothalamic development. Institute for Genetics, Cologne, Germany. Invited seminar. 2010 Importance of metabolic hormones for hypothalamic development. Workshop for the “Study of mechanisms underlying the early programming of modern diseases”, Strasbourg, France. Symposium. Neuroprogramming actions of ghrelin on hypothalamic appetite-related circuits. 14th Annual meeting of the LARC-Neuroscience network, Lille, France. Selected short talk. 2008 Maternal diabetes compromises hypothalamic organization and induces leptin resistance in the offspring. 12th Annual meeting of the LARC-Neuroscience network, Rouen France. Selected short talk. Teaching Activities2012-present Regular teaching activities in the Master of Science program and in the Cologne Graduate School of Ageing Research, Cologne, Germany2008-2012 Biochemistry lecture series and lab practical classes at the University of Medicine, Lille, FranceResearch-related Activities2018 Max Planck Day2017-present Cologne Graduate School of Ageing Research Steering Committee2016-present Ad-hoc Reviewer for Molecular Metabolism, PLOS ONE, Frontiers in Neuroscience and Frontiers in Endocrinology2013-2016 CECAD Ph.D. and Postdoc Steering Committee2015-2017 Initiator and co-organizer of the “What’s Next” lecture series aimed to support career development of Ph.D. students and Posdoc fellows of the Cologne Life Science Campus Co-organizer of the Ph.D. and Postdocs CECAD Retreat2009-2011 Ph.D. Student Steering Committee of the JParc Research Center, Lille2008-2012 Co-organizer of various public relation activities, e.g. Researchers’ Night, Brain WeekMemberships FENS SNE (French Society for Neuroscience)
Max Planck Institute for Metabolism Research Germany
  • Vortrag Transgenerational effects in the neuronal control of metabolism Speaker
    Datum: 14.05.2021 , Zeit: 16:58 | Thema: Grundlagenwissenschaft

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