Prof. Dr. Heiko Lickert General information Date of birth: 12-12-1970 Institution: Institute of Diabetes and Regeneration Research (IDR) Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München Ingolstaedter Landstraße 1, D-85764 Neuherberg Phone +49 (0) 89 3187-3760 E-mail: heiko.lickert@helmholtz-muenchen.de Web: https://www.helmholtz-muenchen.de/idr Current position: Director, Institute for Diabetes and Regeneration Research (IDR), Helmholtz Center Munich and Professor and Chair of Beta Cell Biology, Medical Faculty, Technical University Munich Education and academic degrees 1999 – 2001 PhD Studies; PhD thesis: “Wnt/β-Catenin Signalling in the Endoderm” - Overall mark: summa cum laude; Albert-Ludwigs University Freiburg and Max Planck Institute for Immunobiology Freiburg, Department of Molecular Embryology, Prof. Rolf Kemler 1998 Diploma Thesis: “Influence of E-Cadherin Phosphorylation on Cell-Cell Adhesion” (mark: 1.0); Max-Planck Institute for Immunobiology Freiburg Department of Molecular Embryology, Prof. Rolf Kemler 1992 – 1997 Studies of Biology at Albert-Ludwigs University Freiburg, Cell Biology, Molecular Biology, Biochemistry and Pharmacology (Mark: 1.1) Professional career 2015 Visiting Professorship, Raine Medical Research Foundation, University of Western Australia Since 2011 Director, Institute for Diabetes and Regeneration Research (IDR), Helmholtz Center Munich Since 2011 Full (W3) Professor and Chair of Beta Cell Biology, Medical Faculty, Technical University Munich (TUM) 2009 – 2011 Principal Investigator, Endoderm Development and Regeneration; HelmholtzZentrum münchen - Institute for Stem Cell Research 2005 – 2009 Junior Group Leader, Endoderm Development and Regeneration; HelmholtzZentrum münchen - Institute for Stem Cell Research 2002 – 2004 Post-Doctoral Studies; Samuel Lunenfeld Research Institute Mount Sinai Hospital, Toronto, Canada Department of Fetal Health and Development, Prof. Janet Rossant 2002 Post-Doctoral Fellow; Max Planck Institute for Immunobiology Freiburg, Department of Molecular Embryology, Prof. Rolf Kemler Honors and Awards 2018 VdFF Award for Interdisciplinary Cooperation – Verein der Freunde und Förderer des Helmholtz Zentrum München (VdFF) 2011 Paula and Richard von Hertwig Award for Interdisciplinary Cooperation 2010 ERC Starting Grant – European Research Council (ERC) 2005 Emmy-Noether Junior Group - German Research Foundation (DFG) 2003 Otto-Hahn Medal – Max-Planck Society 2002 Hans-Spemann Award - Albert-Ludwigs University Freiburg 10 selected, most relevant publications (peer reviewed) h-index: 38, i10-index: 65 (Google Scholar) Complete List of Published Work (100 items): http://www.ncbi.nlm.nih.gov/pubmed?term=Lickert%20H 1. Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Böttcher A, Sánchez-Garrido M, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, Yesildag B, Neelakandhan A, Jensen CB, Cornu M, Yang B, Finan B, DiMarchi R, Tschöp MH, Theis F, Hofmann SM, Müller TD, Lickert H. Targeted pharmacological therapy restores β-cell function for diabetes remission. Nature Metabolism. In press 2. Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina K, Salinno C, Engert S, Burtscher I, Böttcher A, Theis F, Lickert H and Bakhti M. (2019) Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 146(12) pii: dev173849. 3. Cernilogar FM, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, Smialowski P, Groh S, Evenroed IM, Gilfillan GD, Lickert H, Schotta G. (2019) Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2. Nucleic Acids Res. 26;47(17):9069-9086 4. Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R, Theis FJ. (2019) Inferring population dynamics from single-cell RNA-sequencing time series data. Nat Biotechnol. 37(4):461-468 5. Theis F.J. and Lickert H. (2019) A map of β-cell differentiation pathways supports cell therapies for diabetes. Nature 569(7756):342-343 6. Bakhti M, Böttcher A, Lickert H. (2019) Modeling the endocrine pancreas in health and disease. Nat Rev Endocrinol. 15(3) 155-171. 7. Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H. (2017) Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol Metab 25;6(6):524-534 8. Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. (2017) Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 26(4):620-632 9. Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H. (2016) Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. 535(7612) 430-4. 10. Roscioni SS, Migliorini A, Gegg M, Lickert H. (2016), Impact of islet architecture on beta-cell heterogeneity, plasticity and function. Nature Rev Endocrinology 12(12):695-70