Diabetes Online-Kongress 2021
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Dr. Natalie Krahmer
I. Education 2011 PhD (“Summa cum laude“), Max Planck Institute of Biochemistry, Munich and Yale School of Medicine, New Haven, USA Mentor: Prof. Dr. Tobias Walther 2008 Diploma in Biology (Biochemistry, Pharmacology, Physiology), Technical University Munich, with distinction (1.0) II. Professional Qualification Since 01/2019 Group leader, Helmholtz Center Munich, Institute for Diabetes and Obesity, Emmy-Noether research group, Cellular Proteomics and Metabolic Signaling 06/2013-12/2018 Postdoctoral fellow, Max-Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried. “Elucidating cellular processes underlying the development of metabolic diseases by organelle proteomics”. Mentor: Prof. Matthias Mann 03/2008-07/2011 PhD, Max-Planck Institute of Biochemistry, Martinsried/ Yale School of Medicine, USA, “Analysis of Lipid Droplet Proteins and their Contribution to Phospholipid Homeostasis during Lipid Droplet Expansion”. Mentor: Prof. Tobias Walther 2010-2011 Collaboration and in total 6 months of research visits, University of California San Francisco, Gladstone Institute of Cardiovascular Disease, San Francisco, USA, Mentor: Prof. Robert Farese 03/2007-01/2008 Diploma Thesis (1.0), Max-Planck Institute of Biochemistry, Department of Cellular Biochemistry, Martinsried, “Functional characterization of the interaction between RuBisCO and the assembly chaperone RbcX”. Mentor: Prof. Franz Ulrich Hartl 10/2004-04/2005 Research Visit, University of California San Francisco, USA. “Crystallization and structural analysis of the luminal domain of Ire1, a UPR sensor”. Mentor: Prof. Peter Walter III. Awards 2020 ESFD/Novo Nordisk Foundation Future Leader Award 2019 DFG Emmy-Noether Programme IV. Selected publications 1 Seebacher, F., Zeigerer, A., Kory, N. & Krahmer, N. Hepatic lipid droplet homeostasis and fatty liver disease. Semin Cell Dev Biol 108, 72-81, doi:10.1016/j.semcdb.2020.04.011 (2020). 2 Schwerbel, K. et al. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J Hepatol 73, 771-782, doi:10.1016/j.jhep.2020.04.031 (2020). 3 Schriever, S. C. et al. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. J Clin Invest 130, 6093-6108, doi:10.1172/JCI136363 (2020). 5 Cinque, L. et al. MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. EMBO J 39, e105696, doi:10.15252/embj.2020105696 (2020). 6 Seitz, S. et al. Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. Nat Metab 1, 1009-1026, doi:10.1038/s42255-019-0124-x (2019). 7 Sacco, F. et al. Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets. Cell Metab 29, 1422-1432 e1423, doi:10.1016/j.cmet.2019.02.012 (2019). 9 Krahmer, N. et al. Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. Dev Cell 47, 205-221 e207, doi:10.1016/j.devcel.2018.09.017 (2018). 12 Wilfling, F. et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell 24, 384-399, doi:10.1016/j.devcel.2013.01.013 (2013). 13 Krahmer, N. et al. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics 12, 1115-1126, doi:10.1074/mcp.M112.020230 (2013). 14 Krahmer, N., Farese, R. V., Jr. & Walther, T. C. Balancing the fat: lipid droplets and human disease. EMBO Mol Med 5, 973-983, doi:10.1002/emmm.201100671 (2013). 15 Krahmer, N. et al. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab 14, 504-515, doi:10.1016/j.cmet.2011.07.013 (2011).
Helmholtz Zentrum München Germany
  • Vortrag Proteom-Profile deuten auf eine zelluläre Reorganisation bei einer Fettleber hin Speaker
    Datum: 14.05.2021 , Zeit: 10:34 | Thema: Grundlagenwissenschaft