Diabetes Online-Kongress 2021
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Dr. Meriem Ouni
Date and place of birth 06. August 1985 in Tunis, TunisiaAcademic Position11/2015 - now Post-Doc in the department of experimental diabetology in German Institute of Human Nutrition (DIfE) Potsdam-Rehbruecke, Germany Education09/2011 – 07/2015 University Paris DescartesDoctorant Research unit INSERM U986, Gene Therapy, Genetics and Epigenetics in child neurology, endocrinology and development, Le Kremlin-Bicêtre, France.Dissertation topic: “DNA methylation variability at IGF1 locus”. Grade: Very honorable (in french: trés honorable avec felicitation du jury)09/2008 - 10/2010 University Tunis El ManarMaster of Genetics and Bioressources Master thesis performed in Research unit INSERM U1016, Genetics and Epigenetics of reproduction, Cochin Institute, Paris, FranceTopic: “Identification of QTL involved in fertility defects in interspecific recombinant congenic lines mice « IRCS»”.Grade: Very Good09/2004 - 09/2008 University Tunis El ManarMagister degree in Biological Sciences and Biotechnology Grade: GoodAWARDS02/2020 DDG Silivia King award for publication “Dynamic changes of muscle insulin sensitivity after metabolic surgery”. Nature Communications, September 2019.04/2019 DZD Award 2019 for a poster presented in EASD congress entitled “Epigenetic response to bariatric surgery in human skeletal muscle” 01/2016 – 12/2018 Grant from German center for diabetes research (DZD) for collaboration project within DZD/PI: Pr. Annette Schürmann, Pr. Michael Roden and Co-PI: Meriem Ouni, Sofiya Gancheva on the topic: “Dynamic changes of muscle insulin sensitivity after metabolic surgery” (50,000 euro) 03/2016 – 01/2017 DIfE-Internal project funding on the topic: “Novel miRNA involved in type 2 diabetes” (15,000 euro)10/2011 – 09/2014 Grant Doctoral fellow grant from French ministry of research (highly competitive) Publication list1. Ouni M,..,. Schürmann A. Epigenetic alteration in pancreatic islets before the onset of type 2 diabetes. Diabetes 2020; 69(11):2503-2517.2. Gässler A,..,Ouni M,…, Annette Schürmann, Heike Vogel. Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells Journal of Molecular Metabolism 2020; 41:101042. 3. 4. Bódis K,..,Ouni M,…Schürmann A,…, , Szendroedi J; GDS Study Group. Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2020; 105(4). 5. Ouni M and Schürmann A. Epigenetic contribution to obesity, Mammalian Genome 2020; 31(5-6).6. Gottmann P, Ouni M, Zellner L, Jähnert, M Rittig K, Walther D, Schürmann A. Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans. Scientific reports, in press (April, 2020). 7. Gancheva S*, Ouni M*,..,Annette Schürmann, Michael Roden. (*) equal contribution. Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nature Communications 2019; 10(1):4179.8. Saussenthaler S*, Ouni M*, Baumeier C, Laeger T, Gottmann P, Christmann S and Schürmann A. Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein“. (*) equal contribution. The Journal of Nutritional Biochemistry 2019; 63: 109-116. 9. Wittenbecher C, Ouni M, Kuxhaus O, Jähnert M; Gottmann P; Teichmann A; Meidtner K; Kriebel J; Grallert H, Pischon T; Boeing H, Schulze M and Schürmann. Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes. Diabetes 2019; 68(1):188-197. 10. Gottmann P, Ouni M, Saussenthaler S, Roos J, Stirm L, Jähnert M, Kamitz A, Hallahan N, Jonas W, Fritsche A, Häring HU, Staiger H, Blüher M, Fischer-Posovszky P, Vogel H, Schürmann A. A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Molecular Metabolism 2018; 11:145-159.11. Ouni M, Castell AL, Rothenbuhler A, Linglart A, Bougnères P. Higher methylation of the IGF1 P2 promoter is associated with idiopathic short stature. Clinical Endocrinology 2016; 84(2):216-221.12. Ouni M, Belot MP, Castell AL, Fradin D. The P2 promoter of the IGF1 gene is a major epigenetic locus for GH responsiveness. The Pharmacogenomics Journal, 2016; 16(1):102-6.13. Ouni M, Castell AL, Linglart A, Bougnères P. Genetic and epigenetic modulation of growth hormone sensitivity studied with the IGF1 generation test. Journal of Clinical Endocrinology and Metabolism 2015; 100(6):E919-25.14. Ouni M, Gunes Y, Belot MP, Castell AL, Fradin D, Bougnères P. The IGF1 P2 Promoter is an Epigenetic QTL for Circulating IGF1 and Human Growth. Clinical Epigenetics Journal 2015; 13;7:22. 
Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE) Germany
  • Vortrag Epigenetische Übertragung des Diabetes Speaker
    Datum: 14.05.2021 , Zeit: 10:58 | Thema: Grundlagenwissenschaft
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