Authors:
Prof Dr Marco Krengli | University Hospital "Maggiore della Carità" | Italy
Felipe A Calvo | Hospital general Universitario Gregorio Marañon | Spain
Prof Dr med Felix Sedlmayer | Paracelsus Medical University Clinics Salzburg | Austria
Claudia Schumacher | St. Elisabeth Hospital Köln-Hohenlind | Germany
Luigi Franco Cazzaniga | ASST- PAPA GIOVANNI XXIII | Italy
Marina Alessandro | Città di Castello Hospital | Italy
Antonino De Paoli | Centro di Riferimento Oncologico di Aviano | Italy
Elvio Russi | S. Croce & Carle Teaching Hospital | Italy
Marta Kruszyna-Mochalska | Greater Poland Cancer Centre | Poland
Renzo Corvò | AOU IRCCS San Martino-IST National Cancer Research Institute and University | Italy
Frederik Wenz | University Medical Center Mannheim | Germany
Renzo Mazzarotto | Azienda Ospedaliera Universitaria Integrata | Italy
Fabrizio Fusconi | Ospedale di Spoleto | Italy
Antonella Ciabattoni | San Filippo Neri Hospital | Italy
Reinhilde Weytjens | GZA SINT AUGUSTINUS | Belgium
Giovanni Battista Ivaldi | Fondazione Salvatore Maugeri | Italy
Antonella Baldissera | Bellaria Hospital | Italy
Carla Pisani | University Hospital "Maggiore della Carità" | Italy
PhD Virginia Morillo | Consorcio Hospitalario Provincial de Castellón | Spain
Mattia Falchetto Osti | Sant' Andrea Hospital | Italy
Nuran Bese | ACIBADEM MASLAK HOSPITAL | Turkey
Gianpiero Catalano | Multimedica Group | Italy
Antonio Stefanelli | University Hospital S'Anna, Ferrara | Italy
Cinzia Iotti | Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico | Italy
Luigi Tomio | Santa Chiara Hospital | Italy
Vincenzo Fusco | I.R.C.C.S. - Ospedale Oncologico Regionale | Italy
Ignazio Azinovic | Imoncology | Spain
Marisel Aguilar Herrera | Clinica Biblica Hospital | Costa Rica
Francesco Ricchetti | Sacro Cuore Don Calabria Hospital | Italy
Nina Kirsanova | Almaty cancer center | Kazakhstan
Wojciech Polkowski | Medical University of Lublin | Poland
Alfio Di Grazia | Istituto Oncologico del Mediterraneo | Italy
Alessandro Gava | Ospedale Ca' Foncello | Italy
Liana Abdach | RAMBAM Health Care Campus | Israel
Cristiana Vidali | Azienda Ospedaliero Universitaria Trieste | Italy
Jean-Bernard Dubois | Institut Régional du Cancer | France
Vincenzo Valentini | Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli | Italy
Dr med Leonardo Badinez | Fundación Arturo López Pérez | Chile
Ayse Y Altinok | Istanbul Medipol University | Turkey
Umberto Ricardi | University of Turin School of Medicine | Italy
Marco Lioce | IRCCS Ospedale Oncologico | Italy
Omur Alan | Okmeydani Training and Research Hospital | Turkey
Pedro Lara | Dr. Negrín University Hospital | Spain
Ute Ganswindt | Medizinische Universität Innsbruck | Austria
Maia Topeshashvili | Tbilisi Cancer Center | Georgia
Jun Yin | Sichuan Cancer Hospital&Institute | China
Purpose: Data from centres active in intraoperative radiotherapy (IORT) were collected within the International Society of Intraoperative Radiotherapy (ISIORT) program. The purpose of the present analysis was to analyse and report the main clinical and technical variables of IORT performed by the participating centres.
Materials and Methods: In 2007, the ISIORT-Europe centres were invited to record demographic, clinical and technical data relating to their IORT procedures in a joint online database.
Results: 12,678 IORT procedures from 45 centres have been recorded from 2007 to 2018. 96% of treatment was performed with electrons, while 496 treatments were performed with x-rays. Median age of patients was 68 years (range: 5 months – 89 years). Gender was female in 81.2% of cases and male in 18.8%. Treatments were curative in 12,167 cases (94.1%) and 3,077 (23.8%) cases were included in study protocols. The most frequent tumour was breast cancer with 9,879 cases (76.4%) followed by rectal cancer with 1,073 cases (8.3%), soft tissue and bone sarcomas with 414 cases (3.2%), prostate cancer with 194 cases (1.5%), gastric cancer with 142 cases (1.1%) and pancreatic cancer with 141 cases (1.1%).
Conclusion: Treatment chronology shows how IORT number of recorded cases increased according with the interest in this ISIORT project. This survey gives an overview of worldwide use of IORT including patient selection criteria and treatment modalities and could represent a basis to design future clinical trials.