Autor:innen:
H. Maalmi (Düsseldorf, DE)
C. Herder (Düsseldorf, DE)
K. Strassburger (Düsseldorf, DE)
S. Urner (Düsseldorf, DE)
K. Jandeleit-Dahm (Düsseldorf, DE)
O. Zaharia (Düsseldorf, DE)
Y. Karusheva (Düsseldorf, DE)
K. Bódis (Düsseldorf, DE)
W. Rathmann (Düsseldorf, DE)
D. Markgraf (Düsseldorf, DE)
V. Burkart (Düsseldorf, DE)
J. Szendrödi (Düsseldorf, DE)
M. Roden (Düsseldorf, DE)
Background: Inflammation has been associated with impaired kidney function in humans with long-standing diabetes. However, it is unclear whether these associations can be extended to middle-aged patients with recent-onset type 2 (T2D) or type 1 diabetes (T1D).
Methods: Seventy-four biomarkers of inflammation were measured using proximity extension assay technology in serum of participants from the German Diabetes Study, which includes people with T2D and T1D with a known diabetes duration of < 1 year and aged 18-69 years. Prospective associations between baseline levels of each biomarker and estimated glomerular filtration rate (eGFR) at 5-year follow-up were assessed using linear regression adjusting for baseline eGFR, age, sex, BMI, HbA1c, known diabetes duration, lipids, hypertension and medication use.
Results: This study included 230 participants (T2D: n = 138, mean age 54 years; T1D: n = 92, mean age 36 years). For T2D, mean (SD) eGFR was 89.3 (15.6) and 85.3 (16.1) mL/min/1.73 m2 at baseline and after 5 years, respectively. For T1D, eGFR was 101.8 (15.3) and 98.8 (15.8) mL/min/1.73 m2 at baseline and after 5 years, respectively. After full adjustment, VEGFA and CD6 as well as FGF5, 4E-BP1 and DNER were positively associated with eGFR in T2D and T1D, respectively, whereas higher MMP10 and CSF1 levels were associated with a decrease in eGFR in T2D. However, none of these associations remained significant after correction for multiple testing.
Conclusions: In middle-aged patients with recent-onset diabetes, biomarkers of inflammation may be associated with changes in eGFR over 5 years, which merits further studies.