Research Profile Heiner Wedemeyer1. General InformationName Wedemeyer, Heiner, Prof. Dr. med. Date of Birth 10.04.1967Sex MaleAffiliation Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Straße 1, D-30625 HannoverPhone: +49-(0)511-532 3306 E-Mail: wedemeyer.heiner@mh-hannover.deCurrent Position Head and Chair of the Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (W3)2. Academic Education 1996 Medical Doctorate (Dr. med.), University of Göttingen, thesis supervisor Prof. Dr. Dr. Detlev Schild1988 - 1996 Studies of Medicine and Musicology, University of Göttingen State license physician 19963. Scientific Degreessince 2020 Full Professor (W3) Head and Chair of the Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School2018 - 2020 Full Professor (W3), Chair (Lehrstuhl) for Internal Medicine and Director, Department of Gastroenterology and Hepatology, Universitätsmedizin Essen, University of Duisburg-Essen2012 - 2018 Managing senior physician and W2 Professor (Associate Professor) in the Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School2009 Außerplanmäßiger Professor (Assistant Professor), Hannover Medical School2004 Habilitation for Experimental Gastroenterology, Hannover Medical School4. Academic and Research PositionsSince 2014 Medical Director Leberstiftungs-GmbH Deutschland2001 - 2012 Resident in Gastroenterology and later senior staff physician; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany1998 - 2000 Research-Fellowship, Liver Diseases Section, NIDDK, NIH, Bethesda, MD, USA 1996 - 1998 Resident, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany5. Additional Information2010 - 2022 Part project leader in the DFG CRC 900: Chronic Infections: Microbial Persistence and its Control; Project A5, Funding Period 1-32016 - 2021 Part project leader in the Thematic Translational Units (TTU) Hepatitis, Project TTU 05.807/816: Novel therapeutic strategies for functional cure of Hepatitis D Virus infection, funded by the German Center for Infection Research (DZIF)2007 - 2019 Part project leader in the DFG CRC 738: Optimization of Conventional and Innovative Transplants; Project B2, Funding Period 1-32019 Associate Editor Gastroenterology2021 Associate Editor Hepatology2015 - 2018 Speaker of the PhD program KlinStrucMed at the Hannover Medical School (MHH) funded by the Else Kroener-Fresenius-Stiftung2015 - 2018 Member of the Steering Committee Hannover Biomedical Research School (HBRS)2013 - 2016 Member of the United European Gastroenterology Scientific Committee2009 - 2011 Secretary General of the European Association for the Study of the Liver (EASL)Since 2002 Scientific Coordination of the German Network of Competence on Viral Hepatitis (Hep-Net) and the German Liver FoundationSince 2011 Coordinator of the Hepatitis Delta International Network (HDIN) Awards and Prizes:2018 Visiting Professor CanHepC2014 Registry Grant Award European Association for the Study of the Liver2012 Gilead Foerderpreis Infektiologie2011 Innovation Award of the German Medical Faculties2011 Rudolph-Schoen-Award2008 Präventionspreis Deutsche Gesellschaft für Innere Medizin2002 Hans-Popper Award International Association for the Study of the Liver 6. Publications (out of 385, h-index 98) 1. Lampertico P, Carrión JA, Curry M, Turnes J, Cornberg M, Negro F, Brown A, Persico M, Wick N, Porcalla A, Pangerl A, Crown E, Larsen L, Yu Y, Wedemeyer H. Real-world Effectiveness and Safety of glecaprevir/pibrentasvir for the Treatment of Patients With Chronic HCV Infection: A Meta-Analysis. J Hepatol 2020; 72: 1112-1121.2. Wedemeyer H, Yurdaydin C, Hardtke S, Caruntu FA, Curescu MG, Yalcin K, Akarca US, Gurel S, Zeuzem S, Erhardt A, Lüth S, Papatheodoridis GV, Keskin O, Port K, Radu M, Celen MK, Idilman R, Weber K, Stift J, Wittkop U, Heidrich B, Mederacke I, von der Leyen H, Dienes HP, Cornberg M, Koch A, Manns MP. Peginterferon alfa-2a plus tenofovir disoproxil fumarate for hepatitis D (HIDIT-II): a randomised, placebo controlled, phase 2 trial. Lancet Infect Dis 2019; 19: 275-286.3. Strunz B, Hengst J, Deterding K, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H*, Björkström NK*. Chronic hepatitis C virus infection irreversibly impacts human NK cell repertoire diversity. Nature Communications 2018; 9: 2275. (*shared senior authorship)4. Deterding K, Spinner CD, Schott E, Welzel TM, Gerken G, Klinker H, Spengler U, Wiegand J, Schulze zur Wiesch J, Pathil A, Cornberg M, Umgelter A, Zöllner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns MP, Wedemeyer H. An open label phase 2 study to investigate six weeks of ledipasvir/sofosbuvir treatment of acute hepatitis C virus genotype 1 monoinfection: The HepNet Acute HCV IV Study. Lancet Infect Dis 2017; 17: 215-222.5. Wranke A, Calle Serrano B, Heidrich B, Kirschner J, Bremer B, Lehmann, P, Hardtke S, Deterding K, Port K, Westphal M, Manns MP, Cornberg M, Wedemeyer H. Antiviral treatment and liver-related complications in hepatitis delta. Hepatology 2017; 65: 414-425.6. Todt D, Gisa A, Radonic A, Nitsche A, Behrendt P, Suneetha PV, Pischke S, Bremer B, Brown RJ, Manns MP, Cornberg M, Bock CT, Steinmann E, Wedemeyer H. In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 2016; 65: 1733-1743.7. Owusu Sekyere S, Suneetha PV, Kraft A, Zhang SH, Dietz J, Sarrazin C, Manns MP, Schlaphoff V, Cornberg M, Wedemeyer H. A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C. J Hepatol 2015; 62: 31-40.8. Di Bisceglie AM, Janczweska-Kazek E, Habersetzer F, Mazur W, Stanciu C, Carreno V, Tanasescu C, Flisiak R, Romero-Gomez M, Fich A, Bataille V, Toh ML, Hennequi M, Zerr P, Honnet G, Inchauspé G, Agathon D, Limacher JM, Wedemeyer H. Efficacy of Immunotherapy With TG4040, Peg-Interferon, and Ribavirin in a Phase 2 Study of Patients With Chronic HCV Infection. Gastroenterology 2014; 147: 119-131.e39. Deterding K, Grüner N, Buggisch P, Wiegand J, Galle PR, Spengler U, Hinrichsen U, Berg T, Potthoff A, Malek NP, Großhennig A, Koch A, Diepolder H, Lüth S, Feyerabend S, Jung MC, Rogalska-Taranta M, Schlaphoff V, Cornberg M, Manns MP, Wedemeyer H, The Hep-Net Acute HCV-III Study Group. Delayed versus immediate treatment for patients with acute hepatitis C: A randomised controlled non-inferiority trial. The Lancet Infectious Diseases 2013; 13: 467-506.10. Wedemeyer H, Yurdaydın C, Dalekos GN, Erhardt A, ÇakaloğluY, Değertekin H, Gürel S, Zeuzem S, Zachou K, Bozkaya H, Koch A, Bock T, Dienes HP, Manns MP, The Hep-Net/International Delta Hepatitis Study Group. Peginterferon plus adefovir versus either drug alone for hepatitis delta. N Engl J Med 2011; 364: 322-31.