By combining insights from both basic animal and human research, the aim of this panel will be to foster our understanding of the translational mechanisms underlying the role of social connectedness and several limbic neuropeptides in the regulation of defensive behaviors and in the neural processes that are disrupted in stress-related disorders such as major depression, post-traumatic stress disorder, and anxiety disorders. Specifically, Rene Hurlemann (RH) will present recent functional MRI (fMRI) data showing that loneliness may confer vulnerability to intrusive memories after trauma exposure in healthy men and that this phenotype relates to altered limbic processing of fear signals. Valery Grinevich (VG) will demonstrate a key role of vasopressin and oxytocin brain circuitries in regulating anxiety behaviors. Ulrike Schmidt (US) will present molecular and clinical data on the function and regulation of neuropeptide (oxytocin, neuropeptide S, neuropeptide Y) signaling in traumatized individuals and various animal models of stress. Anne-Kathrin Gellner (AKG) will present central and peripheral effects of stress-alleviating treatments in mice, encompassing both pharmacological immunomodulation and non-pharmacological intervention through physical activity.
17:37 Uhr
The role of distinct oxytocin brain circuitries in modulating social-emotional behaviors: from partner bonding to anxiety disorders
V. Grinevich (Mannheim, DE)
17:59 Uhr
Regulation and specific functions of neuropeptide signaling in post-traumatic stress disorder
U. Schmidt (Bonn, DE)
18:21 Uhr
Central and peripheral effects of stress-modulating strategies
A. Gellner (Bonn, DE)
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A. Gellner (Bonn, DE)
Social and non-social stress contributes to neuropsychiatric disorders such as depression, post-traumatic stress disorder, and anxiety disorders. Individual levels of stress vulnerability and disease severity occur in both humans and mice after a group of subjects was exposed to the same threat. Understanding modulators of this so-called stress resilience and susceptibility is extremely important as many psychiatric patients frequently relapse or remain chronically disabled in various functional domains. What drives the induction of stress-induced affective and non-affective symptoms and how can they be treated or even prevented?
I will present the behavioral change in various functional domains caused by social and non-social stressors in mice and link it to central and peripheral systems including neuronal and glial brain cell populations, the innate immune system, and metabolic and endocrinological pathways. We explore the impact of pharmacological and non-pharmacological interventions via immunomodulation and physical training on prevention and treatment of these stress effects in rodent models before closing the talk with a discussion of the translational chances and directions emerging from the data.