Psychomotor abnormalities represent a core clinical feature with transdiagnostic importance in psychiatric disorders, but their relevance for individualizing therapeutic options remains unexplored. Psychomotor functioning is defined through the interaction of primary sensorimotor function (e.g., the dopaminergic-based subcortical-cortical motor circuit) and non-motor function, including cognition and emotion, and changes in the underlying neural processes are known to cross diagnostic boundaries of mental illness. The number of neurobiological studies on psychomotor functioning in psychiatric disorders has steadily increased over the last two decades. In recognition of this development, this symposium will present and discuss recent experimental work on neural mechanisms and clinical implications of psychomotor dysfunction in (1) vulnerable populations (e.g. ultra-high risk individuals, heavy cannabis users and schizotypal disorders), (2) schizophrenia and depression, and (3) catatonia. This symposium will bring clinicians and scientists together to appreciate advantages and challenges of psychomotor-based transnosologic research. By combining model-based approaches and empirical evidence, this symposium aims to contribute to the further development of a dimensional and psychomotor domain-based research agenda, which will lead to a better understanding of positive, negative, disorganized and cognitive symptoms in psychiatric disorders. Through such neural and behavioral characterization of psychomotor mechanisms, this symposium will contribute to the dimensional dissection of severe mental illness and provide preliminary markers for individualization of therapy in the psychomotor domain.